Nakamura, Michihiro Yamaguchi University KAKEN Search Researchers
Hayashi, Koichiro Nagoya University KAKEN Search Researchers
Kubo, Hitoshi Fukushima Medical University KAKEN Search Researchers
Harada, Masafumi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Izumi, Keisuke Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tsuruo, Yoshihiro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yogo, Toshinobu Nagoya University
Multimodal imaging using novel multifunctional nanoparticles provides new approach to biomedical field. Thiol-organosilica nanoparticles containing iron oxide magnetic nanoparticles (MNPs) and rhodamine B (thiol OS-MNP/Rho) were applied to multimodal imaging of hepatic tumor of Long−Evans Cinnamon (LEC) rat. The magnetic resonance imaging (MRI) of LEC rats revealed tumors in the liver clearly and semi-quantitatively due to a labeling of macrophages in liver. The fluorescent imaging (FI) showed abnormal fluorescent patterns of the liver at the mesoscopic level that was between macroscopic and microscopic level. We performed correlation analysis between optical imaging including FI and MRI. We found that the labeled macrophages located specific area in the tumor tissue and influenced the tumor size on MRI. In addition histological observation showed the labeled macrophages related specific tissue in the pathological region. We demonstrated a new approach to evaluate tumor tissue at the macroscopic and microscopic level as well as mesoscopic level using multimodal imaging.
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