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ID 109680
Title Alternative
短時間の造影ダイナミック灌流画像を用いた脳腫瘍の質的診断について
Author
Irahara, Saho The University of Tokushima
Obama, Yuki The University of Tokushima
Majigsuren, Mungunkhuyag The University of Tokushima
Khashbat, Delgerdalai The University of Tokushima
Kageji, Teruyoshi The University of Tokushima KAKEN Search Researchers
Keywords
Magnetic resonance imaging (MRI)
Dynamic contrast enhanced (DCE) perfusion
Brain tumor
Two-compartment model analysis
Pharmacokinetic model analysis
Content Type
Thesis or Dissertation
Description
This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL).
Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast Ktrans, extravascular extracellular volume Ve, and fractional plasma volume Vp. We analyzed differences in parameters between tumors using the Mann–Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis.
Mean K trans values of LGG, HGG, metastasis and PCNSL were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each tumors was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each tumors was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other tumor types, low-grade glioma showed lower Ktrans (P < 0.01, sensitivity = 88%, specificity = 100%) and lower Ve (P < 0.01, sensitivity = 96%, specificity = 100%). PCNSL showed higher Ve (P < 0.01, sensitivity = 100%, specificity = 88%), but the other perfusion parameters overlapped with those of different histology.
Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of brain tumors.
Journal Title
SpringerPlus
ISSN
21931801
Publisher
Springer
Volume
4
Start Page
88
Published Date
2015-02-24
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606031003.pdf
論文本文 : LID201606031004.pdf
本論文は, 著者Takashi Abeの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
Copyright: © 2015 Abe et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2898号
Diploma Number
甲医第1272号
Granted Date
2016-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital