ID 111177
Title Alternative
脳腫瘍における動脈スピンラベリング法及び多変量ダイナミック磁化率コントラスト灌流MRI法の比較
ASL and DSC MRI of brain tumors
Author
Khashbat, Delgerdalai Tokushima University
Ganbold, Mungunbagana Tokushima University
Uyama, Naoto Tokushima University
Irahara, Saho Tokushima University
Keywords
magnetic resonance imaging
arterial spin labeling
dynamic susceptibility contrast perfusion
time to maximum
brain tumor
Content Type
Thesis or Dissertation
Description
Purpose : Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. Methods : Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed. Results : ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors. Conclusions : ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
63
Issue
3-4
Start Page
175
End Page
181
Sort Key
175
Published Date
2016-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606101003.pdf
論文本文 : LID201609291002.pdf
本論文は,著者Delgerdalai Khashbatの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2956号
Diploma Number
甲医第1289号
Granted Date
2016-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital