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ID 115628
Title Alternative
腸炎ビブリオは炎症を誘導し、Cystic Fibrosis Transmembrane Conductance Regulatorを介して下痢を誘導する
CFTR associated diarrhea in VP-infection
Author
Iba, Hitomi Tokushima University|Nagasaki International University
Kido, Junko Tokushima University
Hatayama, Sho Tokushima University
Keywords
Vibrio parahaemolyticus
CFTR
inflammation
diarrhea
COX-2
Content Type
Thesis or Dissertation
Description
Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Hence, the aim of this study was to clarify the contribution of CFTR in V. parahaemolyticus-induced diarrhea in a mouse model of intestinal loop fluid accumulation, with CFTR inhibitors and a CFTR knockout model. The results indicated that CFTR plays a critical role in fluid accumulation in response to V. parahaemolyticus infection. We also investigated the inflammatory association in CFTR-mediated V. parahaemolyticus-induced fluid secretion with cyclooxygenase inhibitors and found that fluid accumulation was decreased by inhibition of cyclooxygenase 2 produced by neutrophils. These findings suggest that V. parahaemolyticus-inducing infiltration and activation of neutrophils also participated in CFTR mediated fluid secretion. This study reveals an important relationship between V. parahaemolyticus-induced diarrhea and inflammation in a mouse model.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
1-2
Start Page
59
End Page
70
Sort Key
59
Published Date
2021-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hitomi Ibaの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3471号
Diploma Number
甲栄第282号
Granted Date
2021-01-28
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences