Urinary adiponectin in DKD
Ishizu, Masashi Tokushima University Tokushima University Educator and Researcher Directory
Mori, Hiroyasu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ohishi, Mami Tokushima University
Kuroda, Akio Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Akehi, Yuko Tokushima University
Aihara, Ken-ichi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Aiba, Motohiro Tokushima Bunri University
Kawano, Tomoharu Tokushima Bunri University
Hashida, Seiichi Ehime University
diabetes kidney disease
estimated glomerular filtration rate
Thesis or Dissertation
Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease.
Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR).
Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR.
Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes.
Journal of Diabetes and its Complications
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
|DOI (Published Version)|
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k3503_abstract_review.pdf 305 KB
k3503_fulltext.pdf 994 KB
|MEXT report number||
Doctor of Medical Science
Institute of Advanced Medical Sciences