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ID 111435
Title Alternative
社会経済的格差のネガティブな認識と抑うつ気分は末梢血白血球のPPBPとSLC1A7 遺伝子の発現を低下させる
Author
Fujita, Kinuyo Tokushima University
Saijo, Saki Tokushima University
Nishikawa, Tatsuya Tokushima University
Keywords
subjective socioeconomic status
depressive mood
peripheral blood leukocytes
gene expression
PPBP
SLC1A7
Content Type
Thesis or Dissertation
Description
Inequality in socioeconomic status (SES) is associated with an increased risk for the development of mental health problems. Here, we examined the association between socioeconomic status (SSS) and psychological distress, and measured gene expression signatures in peripheral blood leukocytes responsible for this association, in 129 healthy adults (27 males and 102 females, aged 44.0 ± 13.0 years) working in a private hospital in Japan. Depressive mood was assessed by Zung Selfrating Depression Scale (SDS). A multiple regression analysis adjusted for gender and age showed that subjective SSS was independently and negatively associated with SDS score. We next focused on 9 subjects who exhibited low SSS scores and 11 subjects with high SSS scores. Microarray analysis revealed that levels of 522 mRNAs were differentially expressed in periheral leukocytes between low and high-SSS groups. The differentially expressed genes were preferentially involved in cellular movement or inflammatory responses. Among them, mRNA levels of pro-platelet basic protein (PPBP) and solute carrier family 1 (glutamine transporter), member 7 (SLC1A7) were negatively correlated with SSS scores. Our results re-confirmed the association between negative perception of SES and depressive mood in healthy adults, and suggest a possible involvement of PPBP and SLC1A7 in the association.
Journal Title
Cogent Psychology
ISSN
23311908
Publisher
Cogent OA
Volume
4
Start Page
1338825
Published Date
2017-06-14
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Kinuyo Fujitaの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© 2017 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3129号
Diploma Number
甲医第1363号
Granted Date
2018-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences