ID 111082
Title Alternative
arterial spin labeling法と造影T1強調像の高信号容積の違いが転移性脳腫瘍から神経膠芽腫を区別するのに有用である
ASL for distinguishing GBM from metastasis
Author
Ganbold, Mungunbagana Tokushima University
Khashbat, Delgerdalai Tokushima University
Keywords
arterial spin labeling
perfusion
volumetric analysis
glioblastoma
metastasis
Content Type
Thesis or Dissertation
Description
Purpose : To determine whether differences in tumor volume between arterial spin labeling (ASL) and contrast-enhanced T1-weighted MR images (CE+T1WI) can help differentiate glioblastoma (GBM) from brain metastasis. Materials and methods : Patients with a diagnosis of GBM (n=25) or brain metastasis (n=13) were examined by both conventional and ASL MR imaging. Volumes of interest with high signal intensity on ASL and CE+T1WI were defined using three dimensional analysis software. Tumor volume difference (ASL-CE) and tumor volume ratio (ASL/CE) were obtained. Absolute maximal tumor blood flow (TBF) and TBF ratio (normalized to white matter) were also measured. The Mann-Whitney U test and receiver operating characteristic curve analysis were performed to compare measurements between the tumor groups. Results : Both tumor volume difference and tumor volume ratio were significantly higher in GBM than in metastasis. Both TBF and TBF ratio were higher for GBM than for metastasis, but the differences were not significant. Conclusion : The difference in tumor volume as measured by ASL high signal intensity and CE+T1WI might be useful for differentiating GBM from metastasis, whereas ASL-derived TBF is insufficient.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
64
Issue
1-2
Start Page
58
End Page
63
Sort Key
58
Published Date
2017-02
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704141003.pdf
論文本文:LID201704141004.pdf
本論文は,著者Mungunbagana Ganboldの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3019号
Diploma Number
甲医第1323号
Granted Date
2017-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital