ASL for Grading Nonenhancing Astrocytoma
Khashbat, Delgerdalai Tokushima University
Harada, Masafumi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Abe, Takashi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ganbold, Mungunbagana Tokushima University
Iwamoto, Seiji Tokushima University KAKEN Search Researchers
Uyama, Naoto Tokushima University
Irahara, Saho Tokushima University
Otomi, Youichi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kageji, Teruyoshi Tokushima University KAKEN Search Researchers
arterial spin labeling
Purpose: We evaluated the utility of arterial spin labeling (ASL) imaging of tumor blood flow (TBF) for grading non-enhancing astrocytic tumors.
Materials and Methods: Thirteen non-enhancing astrocytomas were divided into high-grade (n = 7) and low-grade (n = 6) groups. Both ASL and conventional sequences were acquired using the same magnetic resonance machine. Intratumoral absolute maximum TBF (TBFmax), absolute mean TBF (TBFmean), and corresponding values normalized to cerebral blood flow (TBFmax and TBFmean ratios) were measured. The Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were used to assess the accuracy of TBF variables for tumor grading.
Results: Compared with low-grade astrocytoma, high-grade astrocytoma exhibited significantly greater absolute TBFmax (90.93 ± 24.96 vs 46.94 ± 20.97 ml/100 g/min, P < 0.001), TBFmean (58.75 ± 19.89 vs 31.16 ± 17.63 ml/100 g/min, P < 0.001), TBFmax ratio (3.34 ± 1.22 vs 1.35 ± 0.5, P < 0.001), and TBFmean ratio (2.15 ± 0.94 vs 0.88 ± 0.41, P < 0.001). The TBFmax ratio yielded the highest diagnostic accuracy (sensitivity 100%, specificity 86.3%), while absolute TBFmean yielded the lowest accuracy (sensitivity 85.7%, specificity 70.1%) by ROC analysis.
Conclusion: Parameters from ASL perfusion imaging, particularly TBFmax ratio, may be useful for distinguishing high-grade from low-grade astrocytoma in cases with equivocal conventional MRI findings.
Magnetic Resonance in Medical Sciences
Japanese Society for Magnetic Resonance in Medicine
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License(https://creativecommons.org/licenses/by-nc-nd/4.0/).
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