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ID 116125
Title Alternative
軽度な慢性ストレスはマウスの睡眠を障害し疼痛感受性を増大させる
Author
Dalanon, Junhel Casinillo Tokushima University
Chavan, Parimal Tokushima University
Keywords
Hyperalgesia
Predictable chronic mild stress
Sleep
Slow-wave activity
Interleukin-6
Tumor necrosis factor-alpha
Content Type
Thesis or Dissertation
Description
Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
11
Start Page
14231
Published Date
2021-07-09
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Junhel Dalanonの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3542号
Diploma Number
甲口第473号
Granted Date
2021-09-09
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Medical Sciences
Oral Sciences
University Hospital