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ID 109666
Title Alternative
血清I型コラーゲンC末端テロペプチド濃度は心血管リスクを有する患者の頚動脈硬化と関連する
ICTP as a marker for atherosclerosis
Author
Onishi, Yukiyo Tokushima University
Dong, Bingzi Tokushima University
Ohguro, Yukari Tokushima University
Fujinaka, Yuichi Tokushima Prefecture Naruto Hospital
Keywords
ICTP
Atherosclerosis
Max IMT
baPWV
Content Type
Thesis or Dissertation
Description
Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.
Journal Title
Endocrine Journal
ISSN
13484540
09188959
NCID
AA12020190
AA10901436
Publisher
一般社団法人 日本内分泌学会
Volume
63
Issue
4
Start Page
397
End Page
404
Published Date
2016-04-25
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201605311001.pdf
論文本文 : LID201605311002.pdf
本論文は, 著者Takeshi Kondoの学位論文として提出され, 学位審査・授与の対象となっている。
公開に関する許諾確認は著者・編集事務局間のメールによる
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2904号
Diploma Number
甲医第1278号
Granted Date
2016-03-07
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences
Institute of Advanced Medical Sciences