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ID 118063
Author
Ohmura, Takuya Biozentrum University of Basel
Hanibuchi, Yuto Tokushima University
Miyazawa, Ryuichiro Tokushima University
Keywords
AIRE
bioinformatics
single-cell RNA-seq
The Cancer Genome Atlas
thymic carcinoma
thymic epithelial tumor
Content Type
Journal Article
Description
Despite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by focusing on AIRE, an mTEC-specific transcriptional regulator that is required for immunological self-tolerance. We found that a large proportion of TCs expressed AIRE with typical nuclear dot morphology by immunohistochemistry. AIRE expression in TCs was supported by the RNA-seq data in the TCGA-THYM database. Furthermore, our bioinformatics approach to the recent single-cell RNA-seq data on human thymi has revealed that TCs hold molecular characteristics of multiple mTEC subpopulations. In contrast, TCs lacked the gene signatures for cTECs. We propose that TCs are tumors derived from mTECs.
Journal Title
Cancer Medicine
ISSN
20457634
Publisher
John Wiley & Sons
Volume
12
Issue
8
Start Page
9843
End Page
9848
Published Date
2023-03-13
Rights
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
Institute of Advanced Medical Sciences
University Hospital