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ID 113635
Author
Murata, Yoshiko Suntory Foundation for Life Sciences
Keywords
mugineic acid
2'-deoxymugineic acid
mugineic acid–iron(III) complex transporter
practical synthesis
mugineic acid probe
Content Type
Journal Article
Description
An organic chemistry approach to the mechanistic elucidation of iron acquisition in graminaceous plants is introduced here. To elucidate this detailed mechanism using phytosiderophores, the efficient synthesis of 2’-deoxymugineic acid (DMA), a phytosiderophore of rice, was established. The synthetic DMA was confirmed to have similar iron transport activity to that of natural mugineic acid (MA). It was also revealed that the addition of synthetic DMA, along with iron, to a rice hydroponic solution enabled the rice to grow well even under an alkaline condition, and DMA clearly showed its high potential as a fertilizer to improve food production. On the other hand, the 2’-hydroxy group of MA was confirmed to serve as a point of introduction for labeling, allowing the synthesis of various mugineic acid derivatives as molecular probes. The incorporation of fluorescent mugineic acid into cells allowed them to be clearly observed by fluorescence confocal analysis, and this provided the first direct experimental evidence of transporter-mediated internalization of mugineic acid into cells.
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
09186158
13475215
NCID
AA10885497
AA11696048
Publisher
The Pharmaceutical Society of Japan
Volume
41
Issue
10
Start Page
1502
End Page
1507
Published Date
2018-10-01
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences