Optical resolution via catalytic generation of chiral auxiliary

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Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/113449

ID	113449
Author	Kiyama, Hiroki Kyoto University Inokuma, Tsubasa Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Kuroda, Yusuke Kyoto University Yamaoka, Yousuke Kyoto University Takasu, Kiyosei Kyoto University Yamada, Ken-ichi Tokushima University Tokushima University Educator and Researcher Directory
Keywords	Optical resolution Chiral alcohols Chiral magnesium phosphate Asymmetric addition Imines
Content Type	Journal Article
Description	A new catalytic method for separating enantiomers of racemic compounds is proposed. Catalytic asymmetric addition of chiral trans-2-substituted cyclohexanols to imines provided diastereomeric mixtures of aminals, and the subsequent separation of the enantiomers by silicagel column chromatography and the hydrolysis of the aminals produced the alcohols in an optically active form.
Journal Title	Tetrahedron Letters
ISSN	00404039
NCID	AA00861801 AA11539822
Publisher	Elsevier
Volume	60
Issue	2
Start Page	175
End Page	177
Published Date	2018-12-03
Rights	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID	348326
DOI (Published Version)	10.1016/j.tetlet.2018.12.006
URL ( Publisher's Version )	https://doi.org/10.1016/j.tetlet.2018.12.006
FullText File	tetlet_60_2_175.pdf 488 KB
language	eng
TextVersion	Author
departments	Pharmaceutical Sciences