ID 113449
Author
Kiyama, Hiroki Kyoto University
Kuroda, Yusuke Kyoto University
Yamaoka, Yousuke Kyoto University
Takasu, Kiyosei Kyoto University
Keywords
Optical resolution
Chiral alcohols
Chiral magnesium phosphate
Asymmetric addition
Imines
Content Type
Journal Article
Description
A new catalytic method for separating enantiomers of racemic compounds is proposed. Catalytic asymmetric addition of chiral trans-2-substituted cyclohexanols to imines provided diastereomeric mixtures of aminals, and the subsequent separation of the enantiomers by silicagel column chromatography and the hydrolysis of the aminals produced the alcohols in an optically active form.
Journal Title
Tetrahedron Letters
ISSN
00404039
NCID
AA00861801
AA11539822
Publisher
Elsevier
Volume
60
Issue
2
Start Page
175
End Page
177
Published Date
2018-12-03
Remark
論文本文は2020-12-03以降公開予定
Rights
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
language
eng
TextVersion
その他
departments
Pharmaceutical Sciences