| ID | 113373 |
| Title Alternative | 過剰な機械的負荷に曝された下顎頭軟骨に対する低出力パルス超音波照射の保護効果
LIPUS effect on osteoarthritic TMJs
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| Author |
Fujita, Mutsumi
Tokushima University
Sato-Shigeta, Minami
Tokushima University
Hassan, Ali H.
King Abdulaziz University
Tanaka, Eiji
Tokushima University
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| Keywords | Temporomandibular joint
Osteoarthritis
Mandibular condyle
Low-intensity pulsed ultrasound
Rats
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| Content Type |
Thesis or Dissertation
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| Description | The aim of this study was to assess the effect of low-intensity pulsed ultrasound (LIPUS) application on rat temporomandibular joints (TMJs) with early-stage of osteoarthritis-like conditions induced by mechanical overloading. Fifteen-week-old male Wistar rats were divided into two experimental groups and a control group (n = 10 each). Both TMJs of all rats in one experimental group were subjected to mechanical overloading for 5 d, and those in the other experimental group were exposed to LIPUS for 20 min/d after overloading. Condyles were assessed using micro-computed tomography, histology and histomorphometry. LIPUS treatment attenuated cartilage degeneration, decreased the number of osteoclastic cells and restored the expression of aggrecan after an initial decrease induced by mechanical overloading. These results indicate that LIPUS may have a protective effect on the early progression of TMJ osteoarthritis.
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| Journal Title |
Ultrasound in Medicine and Biology
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| ISSN | 03015629
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| NCID | AA00876354
AA11541187
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| Publisher | Elsevier B.V.|World Federation for Ultrasound in Medicine and Biology
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| Volume | 45
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| Issue | 4
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| Start Page | 944
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| End Page | 953
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| Published Date | 2019-02-04
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| Remark | 内容要旨・審査要旨・論文本文の公開
本論文は，著者Mutsumi Fujitaの学位論文として提出され，学位審査・授与の対象となっている。 |
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
ETD
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| MEXT report number | 甲第3283号
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| Diploma Number | 甲口第448号
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| Granted Date | 2019-03-22
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| Degree Name |
Doctor of Dental Science
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| Grantor |
Tokushima University
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| departments |
Oral Sciences
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