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ID 116180
Author
Nakamura, Tenta Tokushima University
Zaima, Toshihiro Tokushima University
Fujimoto, Saho Tokushima University
Keywords
total synthesis
natural product
tandem cyclization
equilibrium
alkaloid
Content Type
Journal Article
Description
A concise total synthesis of tronocarpine, a chippiine-type indole alkaloid, was accomplished. The key feature of this total synthesis is a one-pot construction of the pentacyclic skeleton containing an azabicyclo[3.3.1]nonane core by tandem cyclization from an indole derivative having all carbon side chains and functional groups. This tandem cyclization consists of α,β-unsaturated aldehyde formation, intramolecular aldol reaction, six-membered lactamization, azide reduction, and seven-membered lactamization. The stereochemical outcome in this tandem cyclization is controlled by the stereocenter at the C14 position. This strategy can be utilized to synthesize other chippiine-type alkaloids with azabicyclo[3.3.1]nonane skeletons.
Journal Title
Angewandte Chemie International Edition
ISSN
14337851
15213773
NCID
AA0052535X
Publisher
Wiley-VCH|German Chemical Society
Volume
60
Issue
2
Start Page
635
End Page
639
Published Date
2020-09-24
Rights
This is the peer reviewed version of the following article: A. Nakayama, T. Nakamura, T. Zaima, S. Fujimoto, S. Karanjit, K. Namba, Angew. Chem. Int. Ed. 2021, 60, 635., which has been published in final form at https://doi.org/10.1002/anie.202009966. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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language
eng
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departments
Pharmaceutical Sciences