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ID 117329
Author
Kimura, Yuki Tokushima University
Ohashi, Eisaku Tokushima University
Taniguchi, Takashi Tokushima University
Imagawa, Hiroshi Tokushima Bunri University
Content Type
Journal Article
Description
The first total syntheses of two 4,10-dihydroxy 8,12-guaianolides that were reported to be natural products, were achieved. Toward the syntheses of a collection of related guaianolides, the typical 5,7-fused system of 8,12-guaianolides was constructed by a ring expansion reaction of a hydroxylated coronafacic acid analog that can be practically synthesized and optically resolved. The total syntheses of these compounds revealed that the previously reported structures of both natural products were incorrect.
Journal Title
Organic Letters
ISSN
15237060
15237052
NCID
AA11347843
AA1218968X
Publisher
ACS Publications
Volume
24
Issue
17
Start Page
3297
End Page
3301
Published Date
2022-04-21
Rights
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.2c01215.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences