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ID 115606
Author
Ikeda, Mayumi Tokushima University
Ishima, Yu Tokushima University|Monash University Malaysia Tokushima University Educator and Researcher Directory
Chuang, Victor T. G. Monash University Malaysia
Sakai, Maki Tokushima University
Osafune, Hiroki Tokushima University
Watanabe, Hiroshi Kumamoto University
Maruyama, Toru Kumamoto University
Otagiri, Masaki Sojo University
Akaike, Takaaki Tohoku University
Keywords
polysulfide
biological fluids
circadian rhythm
aging
Content Type
Journal Article
Description
Intracellular polysulfide could regulate the redox balance via its anti-oxidant activity. However, the existence of polysulfide in biological fluids still remains unknown. Recently, we developed a quantitative analytical method for polysulfide and discovered that polysulfide exists in plasma and responds to oxidative stress. In this study, we confirmed the presence of polysulfide in other biological fluids, such as semen and nasal discharge. The levels of polysulfide in these biological fluids from healthy volunteers (n = 9) with identical characteristics were compared. Additionally, the circadian rhythm of plasma polysulfide was also investigated. The polysulfide levels detected from nasal discharge and seminal fluid were approximately 400 and 600 μM, respectively. No correlation could be found between plasma polysulfide and the polysulfide levels of tear, saliva, and nasal discharge. On the other hand, seminal polysulfide was positively correlated with plasma polysulfide, and almost all polysulfide contained in semen was found in seminal fluid. Intriguingly, saliva and seminal polysulfide strongly correlated with salivary amylase and sperm activities, respectively. These results provide a foundation for scientific breakthroughs in various research areas like infertility and the digestive system process.
Journal Title
Molecules
ISSN
14203049
Publisher
MDPI
Volume
24
Issue
9
Start Page
1689
Published Date
2019-04-30
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
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language
eng
TextVersion
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departments
Pharmaceutical Sciences