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ID 114021
Title Alternative
Sarcopenia and AGEs in type 1 diabetes
Author
Araki, Michiko Tokushima University
Suzuki, Reiko Tokushima University
Akehi, Yuko Tokushima University
Keywords
Advanced glycation end-products
Sarcopenia
Type 1 diabetes
Content Type
Journal Article
Description
Accumulation of advanced glycation end-products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence is a proposed marker for accumulation of AGEs in the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia and muscle function of Japanese patients with type 1 diabetes. A total of 36 patients with type 1 diabetes participated in the present cross-sectional study. Sarcopenia parameters (skeletal muscle mass index and knee extension strength) were compared with subcutaneous AGEs accumulation using skin autofluorescence. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (men 0.0%, women 22.2%) and 47.2% (men 22.2%, women 55.6%), respectively. Knee extension strength was negatively correlated with skin autofluorescence (r² = 0.14, P < 0.05), but not with skeletal muscle mass index. In conclusion, the AGEs accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes.
Journal Title
Journal of Diabetes Investigation
ISSN
20401124
Publisher
Asian Association for the Study of Diabetes|John Wiley & Sons Australia
Volume
8
Issue
3
Start Page
377
End Page
382
Published Date
2016-10-11
Rights
© 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License(https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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DOI (Published Version)
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language
eng
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departments
Institute of Advanced Medical Sciences