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ID 114023
Title Alternative
Osteocalcin and body fat in type 1 diabetes
Author
Takashi, Yuichi Tokushima University
Ishizu, Masashi Tokushima University
Miyashita, Kazuyuki Osaka University
Sakamoto, Fumie Osaka University
Katakami, Naoto Osaka University
Matsuoka, Taka-aki Osaka University
Yasuda, Tetsuyuki Osaka Police Hospital
Hashida, Seiichi Tokushima Bunri University
Content Type
Journal Article
Description
The objective of the present study was to investigate the correlations between serum under-carboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with% body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes.
Journal Title
PLOS ONE
ISSN
19326203
Publisher
PLOS
Volume
14
Issue
5
Start Page
e0216416
Published Date
2019-05-03
Rights
© 2019 Takashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version)
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language
eng
TextVersion
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departments
Institute of Advanced Medical Sciences