Effect of biopsy on survival of melanoma patients
Yamashita, Yutaro The University of Tokushima Tokushima University Educator and Researcher Directory
Hashimoto, Ichiro The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Abe, Yoshiro The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Seike, Takuya The University of Tokushima KAKEN Search Researchers
Okawa, Katsumasa The University of Tokushima
Senzaki, Yuichi The University of Tokushima
Murao, Kazutoshi The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kubo, Yoshiaki The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakanishi, Hideki The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Thesis or Dissertation
Background Cutaneous malignant melanoma has a poor prognosis. The detrimental effect of incisional biopsies on the outcome of malignant melanoma has been debated. The aim of this study was to determine the effect of the presence and type of biopsy on the prognosis of malignant melanoma.
Methods The medical records of 109 malignant melanoma patients treated at Tokushima University Hospital from 1983 to 2007 were reviewed. After excluding 28 cases with stage 0 disease or incomplete data, 81 cases were analyzed in detail with respect to patient sex, age, tumor site, clinical stage at diagnosis, presence of ulceration or lymph node metastasis, and prognosis. The five-year survival and five-year disease-free survival rates of patients who underwent incisional or excisional biopsies were compared with those who did not undergo a biopsy.
Results The male-to-female ratio was 1:1.19. The mean age was 61.3 years (range, 19–93 years). The most common site was a lower extremity, and the most common clinical stage was stage II. No significant differences in clinicopathological features, five-year survival rates, and five-year disease-free survival rates were observed among the three groups.
Conclusions The presence and type of biopsy neither affected the metastatic rate nor the prognosis of malignant melanoma. The use of incisional biopsies is not encouraged because tumor thickness cannot be measured accurately. However, they may be helpful for confirming the diagnosis if an excisional biopsy cannot be performed.
Archives of Plastic Surgery
Korean Society of Plastic and Reconstructive Surgeons
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/ ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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o2110_abstract_review.pdf 159 KB
o2110_fulltext.pdf 148 KB
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Doctor of Medical Science