Hypoxia-inducible factor-1 : その発現制御および口腔扁平上皮癌における関わり

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that controls the hypoxic response of mammalian cells. HIF-1 plays crucial roles by regulating the transcription of the target genes, which are involved in energy metabolism, angiogenesis, cell proliferation/apoptosis, cell invasion/metastasis, drug resistance. The regulation of HIF-1 involves a variety of mechanism including transcription, translation, post-translational modification, protein-protein interaction and degradation. In tumor cells, HIF-1 is present at high due to hypoxic conditions, the activation of oncogenes or the inactivation of tumor suppressor genes and HIF-1 levels are associated with aggressive progression, diminished therapeutic response and poor prognosis. We have shown that HIF-1 prevents apoptotic cell death of oral squamous cell carcinoma (OSCC) cells and that the enhanced expression of HIF-1 in OSCC cells is associated with resistance against chemotherapeutic drugs and γ-rays. Therefore, the inhibition of HIF-1 activity is a strategy for treatment of cancer. HIF-1-targeting anticancer would improve the prognosis of many cancers including oral cancer.

公開日:2010年1月24日で登録したコンテンツは、国立情報学研究所において電子化したものです。