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ID 111809
Title Alternative
切迫早産に対する長期入院管理が母児の血中ビタミンD濃度に与える影響
Maternal hospitalization and vitamin D
Author
Yonetani, Naoto Tokushima University
Nakayama, Soichiro Tokushima University
Maeda, Kazuhisa Tokushima University|2) General Perinatal Medical Center, Shikoku Medical Center for Children and Adults KAKEN Search Researchers
Keywords
Hospitalization
Nutrition
Premature Delivery
Umbilical cord
Vitamin D
Content Type
Thesis or Dissertation
Description
Aim: We aimed to evaluate the effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D status.
Methods: This was a retrospective cohort study, spanning 4 years, including 18 women with threatened preterm labor and 36 women with normal pregnancy, who received prenatal care for a singleton pregnancy at our center. Threatened preterm labor cases were women who were admitted to our hospital after the second trimester test, for at least 28 days, during which, the third trimester test was also performed. Controls were randomly sampled from women matched for age as well as the season during which the third trimester test was performed. Serum 25-hydroxyvitamin D concentration in maternal blood was compared between the two groups at second trimester, third trimester and in the umbilical cord blood at delivery.
Results: The mean±SD of maternal serum 25-hydroxyvitamin D concentration in the threatened preterm labor group (14.0±3.0 ng/mL) was significantly lower than that in the control group (17.8±5.9 ng/mL) (p<0.01) in the third trimester, although there was no significant difference in the second trimester (p=0.30). There was a significant reduction (p<0.01) in the maternal serum 25-hydroxyvitamin D from the second to third trimester,in the threatened preterm labor group, compared to the control group (p=0.60). There was no significant difference between the two groups in umbilical cord blood 25-hydroxyvitamin D concentrations at delivery (p=0.41).
Conclusions: Prolonged hospitalization for threatened preterm labor reduced the maternal vitamin D status, but did not influence the neonatal status at delivery.
Journal Title
The Journal of Obstetrics and Gynaecology Research
ISSN
14470756
NCID
AA11082002
Publisher
Wiley
Volume
44
Issue
6
Start Page
1042
End Page
1048
Published Date
2018-03-23
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Naoto Yonetaniの学位論文として提出され, 学位審査・授与の対象となっている。
This is the peer reviewed version of the following article: Yonetani, N. , Kaji, T. , Hichijo, A. , Nakayama, S. , Maeda, K. and Irahara, M. (2018), Effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D levels. J. Obstet. Gynaecol. Res., 44: 1042-1048, which has been published in final form at https://doi.org/10.1111/jog.13620. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3199号
Diploma Number
甲医第1374号
Granted Date
2018-05-24
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences