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ID 117588
Author
Shen, Weilin Kyushu University
Shimajiri, Yasuka Shimane University|EditForce
Kainou, Kumiko Shimane University
Sato, Yuki Tokushima University
Ulla, Anayt Tokushima University
Ninomiya, Miyuki Tokushima University
Ohno, Ayako Tokushima University
Tanaka, Mitsuru Kyushu University
Akama, Kazuhito Shimane University
Matsui, Toshiro Kyushu University
Content Type
Journal Article
Description
We previously reported that intramuscular injections of ubiquitin ligase CBLB inhibitory pentapeptide (Cblin; Asp-Gly-pTyr-Met-Pro) restored lost muscle mass caused by sciatic denervation. Here, we detected Cblin on the basolateral side of Caco-2 cells after being placed on the apical side, and found that cytochalasin D, a tight junction opener, enhanced Cblin transport. Orally administered Cblin was found in rat plasma, indicating that intact Cblin was absorbed in vitro and in vivo. Furthermore, transgenic Cblin peptide-enriched rice (CbR) prevented the denervation-induced loss of muscle mass and the upregulation of muscle atrophy-related ubiquitin ligases in mice. These findings indicated that CbR could serve as an alternative treatment for muscle atrophy.
Journal Title
npj Science of Food
ISSN
23968370
Publisher
Beijing Technology and Business University|Springer Nature
Volume
5
Start Page
25
Published Date
2021-09-09
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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language
eng
TextVersion
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departments
Medical Sciences