ID 113793
Title Alternative
脳腫瘍におけるダイナミック磁化率コントラスト灌流MRIの各種パラメーターに対するintravoxel incoherent motion法とarterial spin labeling法との相関と特徴
Perfusion MRI for brain tumors
Author
Dolgorsuren, Enkh-Amgalan Tokushima University
Keywords
Intravoxel incoherent motion
brain tumor
arterial spin labeling
dynamic susceptibility contrast perfusion
Content Type
Thesis or Dissertation
Description
Purpose : To compare data on brain tumors derived from intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) imaging with multiple parameters obtained on dynamic susceptibility contrast (DSC) perfusion MRI and to clarify the characteristics of IVIM and ASL perfusion data from the viewpoint of cerebral blood flow (CBF) analysis. Methods : ASL-CBF and IVIM techniques as well as DSC examination were performed in 24 patients with brain tumors. The IVIM data were analyzed with the two models. The relative blood flow (rBF), relative blood volume (rBV) corrected relative blood volume (crBV), mean transit time (MTT), and leakage coefficient (K2) were obtained from the DSC MRI data. Results : The ASL-CBF had the same tendency as the perfusion parameters derived from the DSC data, but the permeability from the vessels had less of an effect on the ASL-CBF. The diffusion coefficient of the fast component on IVIM contained more information on permeability than the f value. Conclusion : ASL-CBF is more suitable for the evaluation of perfusion in brain tumors than IVIM parameters. ASL-CBF and IVIM techniques should be carefully selected and the biological significance of each parameter should be understood for the correct comprehension of the pathological status of brain tumors.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
66
Issue
3-4
Start Page
308
End Page
313
Sort Key
308
Published Date
2019-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Enkh-Amgalan Dolgorsurenの学位論文として提出され,学位審査・授与の対象となっている。
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3336号
Diploma Number
甲医第1430号
Granted Date
2019-09-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital