ID | 114515 |
Author |
Yamashita, Akihiro
Kyoto University
Morioka, Miho
Kyoto University
Karagiannis, Peter
Kyoto University
Shima, Nobuyuki
Kyoto University
Tsumaki, Noriyuki
Kyoto University
|
Keywords | Chondrocytes
Articular cartilage
Regeneration
Induced pluripotent stem cells
Transplantation
|
Content Type |
Journal Article
|
Description | Background: A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage.
Main text: We review and discuss the possible use of pluripotent stem cells as a new source for future clinical use. Human induced pluripotent stem cells (hiPSCs) have several advantages over human embryonic stem cells (hESCs). Methods for the generation of chondrocytes and cartilage from hiPSCs have been developed. To reduce the cost of this regenerative medicine, allogeneic transplantation is preferable. hiPSC-derived cartilage shows low immunogenicity like native cartilage, because the cartilage is avascular and chondrocytes are segregated by the extracellular matrix. In addition, we consider our experience with the aberrant deposition of lipofuscin or melanin on cartilage during the chondrogenic differentiation of hiPSCs. Short conclusion: Cartilage generated from allogeneic hiPSC-derived cartilage can be used to repair articular cartilage damage. |
Journal Title |
Inflammation and Regeneration
|
ISSN | 18808190
|
Publisher | BioMed Central|Springer Nature
|
Volume | 38
|
Start Page | 17
|
Published Date | 2018-10-04
|
Rights | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Medical Sciences
|