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ID 114515
Author
Yamashita, Akihiro Kyoto University
Morioka, Miho Kyoto University
Karagiannis, Peter Kyoto University
Shima, Nobuyuki Kyoto University
Tsumaki, Noriyuki Kyoto University
Keywords
Chondrocytes
Articular cartilage
Regeneration
Induced pluripotent stem cells
Transplantation
Content Type
Journal Article
Description
Background: A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage.
Main text: We review and discuss the possible use of pluripotent stem cells as a new source for future clinical use. Human induced pluripotent stem cells (hiPSCs) have several advantages over human embryonic stem cells (hESCs). Methods for the generation of chondrocytes and cartilage from hiPSCs have been developed. To reduce the cost of this regenerative medicine, allogeneic transplantation is preferable. hiPSC-derived cartilage shows low immunogenicity like native cartilage, because the cartilage is avascular and chondrocytes are segregated by the extracellular matrix. In addition, we consider our experience with the aberrant deposition of lipofuscin or melanin on cartilage during the chondrogenic differentiation of hiPSCs.
Short conclusion: Cartilage generated from allogeneic hiPSC-derived cartilage can be used to repair articular cartilage damage.
Journal Title
Inflammation and Regeneration
ISSN
18808190
Publisher
BioMed Central|Springer Nature
Volume
38
Start Page
17
Published Date
2018-10-04
Rights
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
ir_38_17.pdf 2.46 MB
language
eng
TextVersion
Publisher
departments
Medical Sciences