Glucocorticoid-dependent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Presenting with Intracellular Crystalline Inclusions within the Rough Endoplasmic Reticulum

Minato, Masanori; Murakami, Taichi; Takahashi, Naoki; Ono, Hiroyuki; Nishimura, Kenji; Tamaki, Masanori; Nagai, Kojiro; Abe, Hideharu; Iwano, Masayuki; Joh, Kensuke; Doi, Toshio

doi:10.2169/internalmedicine.7118-21

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Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/118015

ID	118015
Author	Minato, Masanori Tokushima University Murakami, Taichi Tokushima University\|Ehime Prefectural Central Hospital KAKEN Search Researchers Takahashi, Naoki University of Fukui Ono, Hiroyuki Tokushima University Nishimura, Kenji Tokushima University Tamaki, Masanori Tokushima University Tokushima University Educator and Researcher Directory Nagai, Kojiro Tokushima University KAKEN Search Researchers Abe, Hideharu Tokushima University KAKEN Search Researchers Iwano, Masayuki University of Fukui Joh, Kensuke The Jikei University School of Medicine Doi, Toshio Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	tubulointerstitial nephritis with IgM-positive plasma cells intracellular crystalline inclusions in the rough endoplasmic reticulum glucocorticoid dependence
Content Type	Journal Article
Description	Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an autoimmune kidney disease characterized by IgM/CD138-double-positive plasma cell infiltration in the tubulointerstitium. A 50-year-old man developed IgMPC-TIN and presented with crystalline inclusions in the rough endoplasmic reticulum. Intracellular crystal formation is a rare finding in paraprotein-related kidney diseases, but this case showed no pathogenic monoclonal immunoglobulin. Prednisolone (PSL, 30 mg) improved the TIN, but PSL tapering resulted in the recurrence of TIN. Combination therapy with 15 mg PSL and 150 mg mizoribine ultimately stabilized TIN. This case offers original evidence concerning the pathophysiology and treatment strategy of IgMPC-TIN.
Journal Title	Internal Medicine
ISSN	13497235
Publisher	The Japanese Society of Internal Medicine
Volume	60
Issue	19
Start Page	3129
End Page	3136
Published Date	2021-10-01
Rights	The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID	381058
DOI (Published Version)	10.2169/internalmedicine.7118-21
URL ( Publisher's Version )	https://doi.org/10.2169/internalmedicine.7118-21
FullText File	internalmedicine_60_19_3129.pdf 2.87 MB
language	eng
TextVersion	Publisher
departments	Medical Sciences University Hospital