ID | 116068 |
Author |
Fukuda, Naoyuki
Tokushima University
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Ishikawa, Kunio
Kyushu University
Akita, Kazuya
Tokushima University
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Kamada, Kumiko
Tokushima University
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Kurio, Naito
Tokushima University
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Mori, Yoshihide
Kyushu University
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Keywords | granular cement
β-tricalcium phosphate
dicalcium phosphate dihydrate
self-setting
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Content Type |
Journal Article
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Description | Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, i.e., β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0–600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at approximately 0.6 MPa, when the Ca-P concentration was 20–600 mmol/L. Due to the setting ability, reconstruction of the rat’s calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, approximately 17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules.
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Journal Title |
Journal of Biomedical Materials Research Part B : Applied Biomaterials
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ISSN | 15524981
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NCID | AA11881538
AA12001425
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Publisher | John Wiley & Sons
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Volume | 108
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Issue | 1
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Start Page | 22
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End Page | 29
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Published Date | 2019-03-18
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Remark | This is the peer reviewed version of the following article: Fukuda, N, Ishikawa, K, Akita, K, Kamada, K, Kurio, N, Mori, Y, Miyamoto, Y. 2020. Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement. J Biomed Mater Res Part B. 2020: 108B: 22– 29., which has been published in final form at https://doi.org/10.1002/jbm.b.34361. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Author
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departments |
Oral Sciences
University Hospital
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