ID | 118434 |
Author |
Moritani, Maki
The University of Tokushima
Tanahashi, Toshihito
The University of Tokushima
Osabe, Dai
Fujitsu Limited
Nomura, Kyoko
Fujitsu Limited
Fujita, Yuka
The University of Tokushima
Keshavarz, Parvaneh
The University of Tokushima
Kunika, Kiyoshi
The University of Tokushima
Nakamura, Naoto
Kyoto Prefectural University of Medicine
Yoshikawa, Toshikazu
Kyoto Prefectural University of Medicine
Ichiishi, Eiichiro
Tohoku University
Shiota, Hiroshi
The University of Tokushima
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Yasui, Natsuo
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Inoue, Hiroshi
The University of Tokushima
Itakura, Mitsuo
The University of Tokushima
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Content Type |
Journal Article
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Description | Background: Chromosome 15q14-22.1 has been linked to type 2 diabetes (T2D) and its related traits in Japanese and other populations. The presence of T2D disease susceptibility variant(s) was assessed in the 21.8 Mb region between D15S118 and D15S117 in a Japanese population using a region-wide case-control association test.
Methods: A two-stage association test was performed using Japanese subjects: The discovery panel (Stage 1) used 372 cases and 360 controls, while an independent replication panel (Stage 2) used 532 cases and 530 controls. A total of 1,317 evenly-spaced, common SNP markers with minor allele frequencies > 0.10 were typed for each stage. Captured genetic variation was examined in HapMap JPT SNPs, and a haplotype-based association test was performed. Results: SNP2140 (rs2412747) (C/T) in intron 33 of the ubiquitin protein ligase E3 component n-recognin 1 (UBR1) gene was selected as a landmark SNP based on repeated significant associations in Stage 1 and Stage 2. However, the marginal p value (p = 0.0043 in the allelic test, OR = 1.26, 95% CI = 1.07–1.48 for combined samples) was weak in a single locus or haplotype-based association test. We failed to find any significant SNPs after correcting for multiple testing. Conclusion: The two-stage association test did not reveal a strong association between T2D and any common variants on chromosome 15q14-22.1 in 1,794 Japanese subjects. A further association test with a larger sample size and denser SNP markers is required to confirm these observations. |
Journal Title |
BMC Medical Genetics
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ISSN | 14712350
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NCID | AA12035063
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Publisher | BioMed Central|Springer Nature
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Volume | 9
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Start Page | 22
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Published Date | 2008-03-27
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Rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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language |
eng
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Publisher
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departments |
AWA Support Center
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences
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