Does the bromocriptine-rebound method improve embryo quality?

Aim: To examine whether the bromocriptine-rebound (BR) method improves
pregnancy outcomes after previous unsuccessful assisted reproductive technology (ART)
attempts. Patients/study design : In this study we retrospectively analyzed data from a
total of 121 women with normal serum prolactin (PRL) levels and a history of repeated
unsuccessful ART procedures. Pregnancy outcomes and hormonal data were compared
between the long protocol and BR method. Both procedures were similar, except that in
the BR method, bromocriptine was administered daily from day 5 of the preceding cycle
until 7 days before ovarian stimulation. Results : The number of fertilized oocytes, cleaved
embryos and transplant embryos were significantly higher with the BR method than
with the long protocol even though the numbers of retrieved oocyte were same in both
groups. The ratio of the good embryos, the clinical pregnancy rate was higher with the
BR method than with the long protocol. The embryo score with the BR method were significantly
higher than that with the long protocol. Conclusion : BR method could provide
the better embryos and improve the transplantation rate in women with previous unsuccessful
ART attempts J. Med. Invest. 58 : 63-66, February, 2011

The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html