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ID 106131
Title Alternative
日本人パーキンソン病患者における両側視床下核深部脳刺激後の神経心理学的および精神医学的評価
Mental changes in PD with STN-DBS
Author
Aono, Michitaka The University of Tokushima|Jounan Hospital
Iga, Jun-ichi The University of Tokushima KAKEN Search Researchers
Ueno, Shu-ichi Ehime University
Agawa, Masahito Naruto Health Insurance Hospital
Tsuda, Toshio Naruto Health Insurance Hospital
Keywords
Anxiety
Cognitive function
Deep brain stimulation
Parkinson’s disease
Subthalamic nucleus
Content Type
Thesis or Dissertation
Description
The physical benefits of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease(PD) patients are well documented, but the mental benefits are uncertain, particularly in Japanese patients. This study evaluated the clinical and neuropsychological characteristics before and after STN-DBS surgery in Japanese PD patients. PD patients (n=13, age 67.0 ± 7.8 years) were evaluated pre-surgery (baseline) and at one and six months post-surgery by two trained psychiatrists. The motor symptoms were assessed by the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score. The neuropsychological and psychiatric tests performed were the Mini-Mental State Examination, the Wisconsin Card Sorting Test (WCST), the verbal fluency test (VFT), the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale (HAM-A). The UPDRS motor score (p<0.001) and HAM-A score (p=0.004) showed significant improvement at one month post-surgery, but a significant decline was observed in the WCST total error (p=0.005) and the semantic VFT score (p<0.001). The phonetic VFT also showed a substantial decline (p=0.015) at one month post-surgery. At six months post-surgery, the improvement in the UPDRS motor score was maintained, and the scores on the neuropsychological and psychiatric tests had returned to baseline. Although bilateral STN-DBS did not appear to have long-term effects on neuropsychological and psychiatric outcomes, the microlesion effects associated with STN-DBS appear to increase the risk of transient cognitive and psychiatric complications. These complications should be monitored by careful observation of neurological and psychiatric symptoms.
Journal Title
Journal of Clinical Neuroscience
ISSN
09675868
NCID
AA10958444
Publisher
Elsevier
Volume
21
Issue
9
Start Page
1595
End Page
1598
Published Date
2014-04-30
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131002.pdf
論文本文 : LID201501221002.pdf
本論文は, 著者Michitaka Aonoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2738号
Diploma Number
甲医第1199号
Granted Date
2014-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences