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ID 114104
Title Alternative
Vitamin B6 and schizophrenia
Author
Keywords
Schizophrenia
Vitamin B6
Pyridoxal
Mendelian randomization
One-carbon metabolism
Homocysteine
Content Type
Journal Article
Description
Accumulating evidence indicates that alterations in one-carbon metabolism may play an important role in the pathogenesis of schizophrenia. We focused on vitamin B6 (pyridoxal), which works as a coenzyme in one-carbon metabolism. We first conducted a case-control study and demonstrated that serum pyridoxal levels were significantly lower in the schizophrenia group than in the control group. Subsequently, we conducted a meta-analysis of case-control studies and achieved the similar result to the case-control study. Finally, we investigated the causality between serum pyridoxal levels and schizophrenia by a Mendelian randomization analysis. However, we could indicate no significant causality between serum pyridoxal levels and schizophrenia in the Japanese population. Further studies such as a longitudinal study will be needed because there are several studies on the benefits of vitamin B6 in schizophrenia.
Journal Title
Vitamins
ISSN
0006386X
2424080X
NCID
AA11693298
Publisher
日本ビタミン学会
Volume
92
Issue
10
Start Page
450
End Page
456
Published Date
2018-10-25
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences