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ID 117248
Author
Beppu, Kana Tokushima University
Matsushima, Rina Tokushima University
Watanabe, Suzuno Tokushima University
Fujimoto, Chisa Tokushima University
Ohnishi, Hiroki Tokushima University
Kawai, Misako Ajinomoto
Matsumoto, Hideki Ajinomoto
Keywords
monosodium glutamate
T1R3 genes
head and neck cancer
dysgeusia
Content Type
Journal Article
Description
(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.
Journal Title
Nutrients
ISSN
20726643
Publisher
MDPI
Volume
13
Issue
9
Start Page
2921
Published Date
2021-08-24
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences
University Hospital