ATP and sleep
Chikahisa, Sachiko The University of Tokushima KAKEN Search Researchers
Séi, Hiroyoshi The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
One of the functions of sleep is to maintain energy balance in the brain. There are a variety of hypotheses related to how metabolic pathways interact with sleep/wake regulation. A major finding that demonstrates an interaction between sleep and metabolic homeostasis is the involvement of adenosine in sleep homeostasis. An accumulation of adenosine is supplied from ATP, which can act as an energy currency in the cell. Extracellularly, ATP can act as an activity-dependent signaling molecule, especially in regard to communication between neurons and glia, including astrocytes. Furthermore, the intracellular AMP/ATP ratio controls the activity of AMP-activated protein kinase, which is a potent energy regulator and is recently reported to play a role in the regulation of sleep homeostasis. Brain ATP may support multiple functions in the regulation of the sleep/wake cycle and sleep homeostasis.
Frontiers in Neurology
Frontiers Media S.A.
© 2011 Chikahisa and Séi. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License(https://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
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