アタラシイ リウマチ チリョウホウ
Clinical efficacy of anti-cytokine therapy in rheumatoid arthritis
Tani, Kenji Department of Internal Medicine and Molecular Therapeutics, Course of Medical Oncology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sone, Saburo Department of Internal Medicine and Molecular Therapeutics, Course of Medical Oncology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
tumor necrosis factor-α
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the progressive destruction of joints. Cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and IL-8 have a critical role in the pathogenesis of RA. Recently, etanercept and infliximab, which block the action of TNF-α, can reduce the disease activity of RA. They act more rapidly to decrease symptoms and slow joint damage in patients with early active RA than methotrexate. This article describes recent studies on anti-cytokine therapy in RA.
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