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ID 110960
Title Alternative
大腸癌における抗EGFR抗体薬治療後のEGFR Downregulationは抗腫瘍効果を予測する
EGFR Down-regulation Predicts anti-EGFR Response
Author
Okada, Yasuyuki Tokushima University
Fukuya, Akira Tokushima University
Fujimoto, Shota Tokushima University
Tsuji, Yasushi Tonan Hospital
Keywords
Colorectal cancer
EGFR
cetuximab
internalization
degradation
Content Type
Thesis or Dissertation
Description
ABC, antibody-binding capacity; ADCC, antibody-dependent cellular cytotoxicity; ATCC, American Type Culture Collection; BSA, bovine serum albumin; CR, complete response; CRC, colorectal cancer; CT, computed tomography; ECACC, European Collection of Authenticated Cell Cultures; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ETS, early tumor shrinkage; FBS, fetal bovine serum; FISH, fluorescent in situ hybridization; HRP, horseradish peroxidase; HSRRB, Health Science Research Resources Bank; IHC, immunohistochemistry; MesNa, Mercaptoethanesulfonic acid sodium; mCRC, metastatic colorectal cancer; mAb, monoclonal antibody; mAbs, monoclonal antibodies; PARP, poly (ADP-ribose) polymerase; PBS, phosphate buffered saline; PD, progressive disease; p-ERK, phosphorylated ERK; PNA-LNA, peptide nucleic acid-locked nucleic acid; PR, partial response; PVDF, polyvinylidene difluoride; RECIST, Response Evaluation Criteria in Solid Tumors; RIKEN BRC, RIKEN BioResource Center; SD, stable disease; SDS, sodium dodecyl sulfate; SDS-PAGE, SDS-polyamide gel electrophoresis; TBS-T, Tris-buffered saline with 0.1% Tween; TGF-α, transforming growth factor-α.
Journal Title
Molecular Cancer Research
ISSN
15417786
15573125
NCID
AA11795083
AA12004955
Publisher
American Association for Cancer Research
Volume
15
Issue
10
Start Page
1445
End Page
1454
Published Date
2017-07-11
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yasuyuki Okadaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3116号
Diploma Number
甲医第1351号
Granted Date
2017-10-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital