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ID 116454
Title Alternative
Polymorphisms and Body Mass Index Across Life Course
Author
Iwase, Madoka Aichi Cancer Center Research Institute|Nagoya University
Matsuo, Keitaro Aichi Cancer Center Research Institute|Nagoya University
Nakatochi, Masahiro Nagoya University
Oze, Isao Aichi Cancer Center Research Institute
Ito, Hidemi Aichi Cancer Center Research Institute|Nagoya University
Koyanagi, Yuriko Aichi Cancer Center Research Institute
Ugai, Tomotaka Aichi Cancer Center Research Institute
Kasugai, Yumiko Aichi Cancer Center Research Institute
Hishida, Asahi Nagoya University
Takeuchi, Kenji Nagoya University
Okada, Rieko Nagoya University
Kubo, Yoko Nagoya University
Shimanoe, Chisato Saga University
Tanaka, Keitaro Saga University
Ikezaki, Hiroaki Kyushu University
Murata, Masayuki Kyushu University
Takezaki, Toshiro Kagoshima University
Nishimoto, Daisaku Kagoshima University
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Suzuki, Sadao Nagoya City University
Watanabe, Miki Nagoya City University
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Kuriki, Kiyonori University of Shizuoka
Kita, Yoshikuni Tsuruga Nursing University
Takashima, Naoyuki Kindai University
Nagino, Masato Nagoya University
Momozawa, Yukihide RIKEN
Kubo, Michiaki RIKEN
Wakai, Kenji Nagoya University
Keywords
obesity
body mass index
genome wide association study
polymorphisms
Content Type
Journal Article
Description
Background: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities.
Methods: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models.
Results: We found a significant association (P < 0.05/282 = 1.77 × 10−4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained, even after additional adjustment for dietary energy intake.
Conclusions: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.
Journal Title
Journal of Epidemiology
ISSN
13499092
09175040
NCID
AA10952696
Publisher
Japan Epidemiological Association
Volume
31
Issue
3
Start Page
172
End Page
179
Published Date
2021-03-05
Rights
This is an open access article distributed under the terms of Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences