ID 111274
Title Alternative
進行頭頸部癌に対して化学放射線療法中の患者において経皮内視鏡的胃瘻造設術が治療中断や栄養状態に及ぼす効果
Efficacy of PEG on head and neck cancer
Author
Goda, Masakazu University of Tokushima KAKEN Search Researchers
Jinnouchi, Osamu University of Tokushima
Takaoka, Tsukasa University of Tokushima
Tamura, Koichi University of Tokushima KAKEN Search Researchers
Furukita, Yoshihito University of Tokushima
Keywords
percutaneous endoscopic gastrostomy
PEG
nutritional support
chemoradiotherapy
head and neck cancer
Content Type
Thesis or Dissertation
Description
Objective : Efficacy of percutaneous endoscopic gastrostomy (PEG) on unplanned treatment interruption and nutritional status was examined in patients undergoing chemoradiotherapy (CRT) for advanced head and neck cancer. Methods :We retrospectively reviewed hospital charts of 44 patients with advanced head and neck cancer who were treated with CRT. Results : CRT-induced mucositis of grade 3 or worse and inadequate oral intake of less than one third of their usual intake developed in 33 patients who were recommended PEG placement, but not in 11 patients. Thirteen patients accepted PEG placement and then completed CRT (compliant group). However, among 20 patients who refused both PEG and nasogastoric tube (NGT) placements (non-compliant group), 10 required unplanned interruptions of CRT at a radiation dose around 30-40 Gy (UI-CRT group) while 10 others could complete CRT without interruption (C-CRT group) CRT. Total serum protein levels were significantly decreased after CRT in all patients. Discussion : It is suggested that therapeutic PEG placement is useful for preventing unplanned interruption of CRT in patients with advanced head and neck cancer. After severe mucositis and inadequate oral intake have developed during CRT, PEG placement should be considered before the radiation therapy dose of 30 Gy.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
3-4
Start Page
173
End Page
176
Sort Key
173
Published Date
2015-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201508041003.pdf
論文本文 : LID201510261013.pdf
本論文は,著者Masakazu Godaの学位論文として提出され,学位審査・授与の対象となっている。
著者表記誤記あり(誤)Koich Tamura→(正) Koichi Tamura
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2864号
Diploma Number
甲医第1253号
Granted Date
2015-07-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital