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ID 114720
Title Alternative
stearoyl-CoA desaturaseの低下は慢性腎臓病における過剰な小胞体ストレスを介して筋萎縮に寄与する
Author
Niida, Yuki Tokushima University
Adachi, Yuichiro Tokushima University
Yoshizawa, Aika Tokushima University
Mori, Yuki Tokushima University
Yamamoto, Hironori Tokushima University|Jin-ai University|University of Fukui KAKEN Search Researchers
Miyazaki, Makoto University of Colorado Denver
Keywords
skeletal muscle atrophy
endoplasmic reticulum (ER) stress
chronic kidney disease (CKD)
stearoyl-CoA desaturase (SCD)
saturated fatty acid (SFA)
Content Type
Thesis or Dissertation
Description
Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.
Journal Title
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
NCID
AA10710201
Publisher
Society for Free Radical Research Japan
Volume
67
Issue
2
Start Page
179
End Page
187
Published Date
2020-09-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Niidaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2020 Society for Free Radical Research Japan
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3419号
Diploma Number
甲栄第280号
Granted Date
2020-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences