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ID 109987
Title Alternative
双極性障害におけるグルタミン酸神経伝達異常に関するMRS研究
Author
Iga, Jun-ichi Tokushima University|Ehime University KAKEN Search Researchers
Inoshita, Masatoshi Tokushima University
Tamaru, Mai Tokushima University
Nakayama-Yamauchi, Chiaki University of Tokushima
Funakoshi, Yasuhiro University of Tokushima
Keywords
Bipolar disorder
glutamate
lithium
sodium valproate
magnetic resonance spectroscopy
Glutamine
Content Type
Thesis or Dissertation
Description
Background: Previous studies of patients with bipolar disorder (BD) using magnetic resonance spectroscopy (MRS) have shown neurophysiological abnormalities related to the glutamate (Glu)-glutamine (Gln) cycle, membrane turnover, and neuronal integrity, although the results were neither consistent nor conclusive. Recently it has been reported the Gln/Glu ratio is the most useful index, quantifying neuronal-glial interactions and the balance of glutamatergic metabolites In this MRS study, we elucidated the abnormalities of metabolites in a larger sample of patients with BD with a high-field MRI system.
Methods: Sixty-two subjects (31 patients with BD and 31 healthy controls [HC]) underwent 3T proton MRS (1H-MRS) of the anterior cingulate cortex (ACC) and left basal ganglia (ltBG) using a stimulated echo acquisition mode (STEAM) sequence.
Results: After verifying the data quality, 20 patients with BD and 23 age- and gender-matched HCs were compared using repeated-measures analysis of covariance (ANCOVA). Compared to the HC group, the BD group showed increased levels of Gln, creatine (Cr), N-acetyl aspartate (NAA), choline (Cho), and an increased ratio of Gln to Glu in the ACC, and increased Gln and Cho in the ltBG. These findings remained after the participants with BD were limited to only euthymic patients. After removing the influence of lithium (Li) and sodium valproate (VPA), we observed activated glutamatergic neurotransmission in the ACC but not in the ltBG. Limitations: The present findings are cross-sectional and metabolites were measured in only two regions.
Conclusions: Our results support a wide range of metabolite changes in patients with BD involved in glutamatergic neurotransmission, membrane turnover, and neuronal integrity. Moreover, the elevation of Gln/Glu ratio suggested that hyperactivity of glutamatergic neurotransmission in the ACC is a disease marker for BD.
Journal Title
Journal of Affective Disorders
ISSN
01650327
NCID
AA00256633
AA1153246X
Publisher
Elsevier
Volume
208
Start Page
139
End Page
144
Published Date
2016-10-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201701101001.pdf
論文本文 : k3000_fulltext.pdf
著者の申請により要約(2017-01-10公開)に替えて論文全文を公開(2018-11-05)
本論文は, 著者Hiroko Kuboの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3000号
Diploma Number
甲医第1305号
Granted Date
2016-11-24
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Academic Support Office for Students with Special Needs
Medical Sciences