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ID 115293
Title Alternative
多重遅延3D動脈スピン標識法で測定した定量的脳血流の再現性および性別および月経周期の違いによる変動性について
Reproducibility of CBF using pCASL
Author
Abe, Yumi Tokushima University
Miyoshi, Mitsuharu GE Healthcare
Kabasawa, Hiroyuki GE Healthcare
Takahashi, Yoshitake FUJIFILM Toyama Chemical
Keywords
neuroimaging
arterial spin labeling (ASL)
cerebral blood flow (CBF)
3DSRT
gender difference
Content Type
Thesis or Dissertation
Description
Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women’s menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
67
Issue
3-4
Start Page
321
End Page
327
Sort Key
321
Published Date
2020-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Maki Otomoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3433号
Diploma Number
甲医第1463号
Granted Date
2020-09-10
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences