| ID | 110669 |
| Author |
Akari, Hirofumi
Department of Virology, The University of Tokushima School of Medicine
Yamamoto, Yoshihiko
Department of Virology, The University of Tokushima School of Medicine
Hiwada, Hiroko
Department of Virology, The University of Tokushima School of Medicine
Saito, Yasuyoshi
Institute for Life Science Research, Asahi Chemical Industry Co. Ltd.
Takayanagi, Noriyasu
Institute for Life Science Research, Asahi Chemical Industry Co. Ltd.
Koyama, A. Hajime
Department of Virology, The University of Tokushima School of Medicine
Adachi, Akio
Department of Virology, The University of Tokushima School of Medicine
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| Keywords | fasudil
protein kinase inhibitor
HIV-1
|
| Content Type |
Journal Article
|
| Description | Fasudil is a potent inhibitor for various protein kinases such as myosin light chain kinase and protein kinase C. It has been used as a drug for improvement of intracranial vasospasm and following ischaemic diseases. In this report, we demonstrate that fasudil suppressed the replication of human immunodeficiency virus type 1 (HIV-1) in mitogen-activated peripheral blood mononuclear cells. Our finding shows that fasudil may be useful as a new and distinct chemotherapeutic agent against HIV-1 infection.
|
| Journal Title |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| NCID | AA11166929
|
| Volume | 44
|
| Issue | 3-4
|
| Start Page | 211
|
| End Page | 214
|
| Sort Key | 211
|
| Published Date | 1998
|
| EDB ID | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Medical Sciences
|
