ID 112090
Title Alternative
Suppression of human immunodeficiency virus type 1 replication by its mutants
変異体によるHIV-1の複製抑制
Author
Inubushi, Ritsuko The University of Tokushima
Shimano, Reika The University of Tokushima
Keywords
HIV-1
Gag
Env
gene therapy
Content Type
Journal Article
Description
Various mutants of human immunodeficiency type 1 (HIV-1) were systematically analyzed with respect to their ability to suppress the replication of wild-type (wt) HIV-1. A total of thirty-six mutants of all nine HIV-1 genes were evaluated for their inhibitory effects in a single-round of viral replication cycle. Some of the gag and env mutants were found to be efficiently interfere with the replication of wt HIV-1. The effective sites were mapped to early and/or late viral replication phase. These mutants are useful for future gene therapy against HIV-1 disease AIDS.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
54
Issue
4
Start Page
282
End Page
287
Sort Key
282
Published Date
1998-08-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences