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ID 114738
Title Alternative
降圧療法としてのニカルジピン塩酸塩を使用する脳卒中急性期患者の静脈炎発症の関連要因
Factors related to the occurrence of phlebitis in acute phase stroke patients receiving intravenous nicardipine
Author
Keywords
Stroke
Nicardipine
Phlebitis
Factors
Content Type
Thesis or Dissertation
Description
This study investigated the incidence of phlebitis associated with continuous nicardipine infusion in patients with acute-phase stroke. To identify patient factors related to the occurrence of phlebitis, and considering blood pressure values during nicardipine administration, we retrospectively investigated the nursing and medical records of 301 patients who were hospitalized for stroke. Of these, 92 patients met the inclusion criteria and had data showing whether phlebitis had occurred. We confirmed that phlebitis occurred in 38 patients (41.3%). Factors found to be significantly related to phlebitis onset were Glasgow Coma Scale (GCS)-verbal (V; p = .020) and -motor (M; p = .007), level of consciousness (total GCS score [(p = .009)]), nicardipine administration time (p = .001), nicardipine dose (p = .000), mean nicardipine rate of administration (p = .000), nicardipine dilution rate (p = .000), mean arterial blood pressure at first insertion (p = .030), and difference in the diastolic blood pressure at first insertion (p = .032). Multiple logistic regression analysis indicated that nicardipine administration time (odds ratio: 1.042, 95% confidence interval: 1.023–1.062, p = .000) was a related factor. Results also suggested that a decreased level of consciousness after the stroke onset (V3 or below and M5 or below) is related to phlebitis occurrence. Patients with stroke having a lower level of consciousness (total GCS score of 12 or below), who are being administered continuous nicardipine infusion, may require more frequent and careful infusion management and needle insertion site observation. Because phlebitis onset occurs after 24 h of continuous infusion, peripheral insertion site catheter replacement should be performed within 24 h.
Journal Title
Journal of Japanese Academy of Neuroscience Nursing
ISSN
21879354
NCID
AA12740790
Publisher
Japanese Academy of Neuroscience Nursing
Volume
6
Issue
1
Start Page
3
End Page
13
Published Date
2019-12-31
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yasuko YOKOIの学位論文として提出され,学位審査・授与の対象となっている。
論文本文は2021-01-01以降公開予定
EDB ID
FullText File
language
jpn
TextVersion
その他
MEXT report number
甲第3420号
Diploma Number
甲保第39号
Granted Date
2020-03-23
Degree Name
Doctor of Health Science
Grantor
Tokushima University
departments
Medical Sciences