Sakai, Waka Tokushima University
Matsui, Naoko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ishida, Mitsuyo Itsuki Hospital
Furukawa, Takahiro Tokushima University Tokushima University Educator and Researcher Directory
Fujita, Koji Tokushima University
Miyamoto, Ryosuke Tokushima University Tokushima University Educator and Researcher Directory
Yamamoto, Nobuaki Tokushima University
Sako, Wataru Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kondo, Kazuya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nishida, Yoshihiko Itsuki Hospital
Mitsui, Takao Tokushima, National Hospital
Izumi, Yuishin Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kaji, Ryuji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Late-onset myasthenia gravis
Thesis or Dissertation
Objective: The continuous increase in the number of patients presenting with late-onset myasthenia gravis (LOMG) underscores the need for a better understanding of the clinical course and the establishment of an optimal therapeutic strategy. We aimed to clarify factors associated with clinical outcomes in LOMG.
Methods: We retrospectively reviewed the clinical profiles of 40 patients with early-onset MG (EOMG) (onset age: 49 years or younger), 30 patients with non-elderly LOMG (onset age: 50–64 years), and 28 patients with elderly LOMG(onset age: 65 years or older) and compared the subgroups according to onset age and thymus status. The evaluated parameters were MGFA classification before treatment, MG-ADL score, complicating diseases, antibody titer, treatment, and MGFA post-intervention status.
Results: Elderly LOMG patients showed transition to generalized symptoms at a higher frequency and underwent thymectomyless frequently than EOMG and non-elderly LOMG patients (p < 0.001). The frequencies of crisis and plasmapheresis were significantly lower in thymectomized LOMG patients without thymoma than in thymectomized LOMG patients with thymoma or non-thymectomized LOMG patients (p < 0.01, P < 0.05, respectively). However, the outcome was not significantly different. All of the thymectomized LOMG patients without thymoma presenting with hyperplasia or thymic cyst had a favorable clinical course.
Conclusions: Our study showed that elderly LOMG patients are more prone to severity, suggesting that they require aggressive immunomodulatory therapy.
本論文は, 著者Waka Sakaiの学位論文として提出され, 学位審査・授与の対象となっている。
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
|DOI (Published Version)|
|URL ( Publisher's Version )|
k3102_abstract_review.pdf 367 KB
k3102_fulltext.pdf 400 KB
|MEXT report number||
Doctor of Medical Science
Institute of Advanced Medical Sciences