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ID 113269
Title Alternative
内因性プロゲステロン分泌は、合成プロゲステロン製剤を用いたホルモン補充凍結胚移植周期において妊娠予後予測因子になり得る
Author
Kawachiya, Satoshi Tokushima University
Bodri, Daniel Kobe Motomachi Yume Clinic
Hirosawa, Toshikazu Kobe Motomachi Yume Clinic
Serna, Jazmina Yao Kobe Motomachi Yume Clinic
Keywords
progesterone
blastocyst transfer
fertilization in vitro
single embryo transfer
luteoplacental shift
dydrogesterone
placental progesterone
Content Type
Thesis or Dissertation
Description
Purpose: A retrospective, cohort study was conducted between 2009 and 2017 in a private infertility center to determine the predictive value of endogenous estrogen (E2) and progesterone (P4) levels in hormone‐replacement frozen embryo replacement (FER) treatment cycles.
Methods: A total of 120 consecutive, infertile patients who became pregnant after FER cycles were analyzed (age: 37.4 ± 4.4 years). Electively vitrified blastocysts were created during natural cycle IVF or mild ovarian stimulation treatments and subsequently transferred through delayed vitrified‐thawed blastocyst transfer cycles supplemented with estrogens and a combination of synthetic progestogens. Serum E2 and progesterone P4 levels were intensively monitored every five days (from the day after embryo transfer until 9w1d of pregnancy) and compared among patients with a subsequent live birth (n = 76) or first‐trimester pregnancy loss (n = 44).
Results: Endogenous placental activity started as early as 5‐6th pregnancy week differing significantly according to pregnancy outcome. For P4, the exponential rise from 6w2d onwards allowed distinguishing between failing and successful conceptions. For P4, lower quartiles of the live birth group did not intersect with upper quartiles of the miscarriage group.
Conclusions: Innovative FER protocols incorporating synthetic progestogens allow the correct measurement of endogenous placental activity and could help to monitor early first‐trimester ART pregnancies.
Journal Title
Reproductive Medicine and Biology
ISSN
14470578
NCID
AA11706516
Publisher
Wiley|Japan Society for Reproductive Medicine
Volume
18
Issue
1
Start Page
91
End Page
96
Published Date
2018-11-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Satoshi Kawachiyaの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial‐NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
© 2018 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3252号
Diploma Number
甲医第1401号
Granted Date
2019-02-06
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences