ID 113613
Title Alternative
Human papillomavirus in maternal milk
Author
Furumoto, Hiroyuki The University of Tokushima KAKEN Search Researchers
Maeda, Kazuhisa The University of Tokushima KAKEN Search Researchers
Keywords
HPV
maternal milk
transmission
Content Type
Journal Article
Description
Objective: Human papillomavirus (HPV) DNA has been detected in the oral cavity of infants and breast cancer tissue, suggesting its vertical transmission through maternal milk. We determined whether HPV is detected in maternal milk and is vertically transmitted by breast feefing.
Methods: Informed consent was obtained, and maternal milk samples (n = 80) were analyzed for high-risk HPV DNA. In 43 women, this DNA was measured in the uterine cervix. In women with positive samples, this DNA was measured in the oral cavities of their children. The domain including HPV E6 and E7 was amplified by polymerase chain reaction using consensus primers, and HPV serotype determined by electrophoresis after restriction enzyme digestion.
Results: High-risk HPV-16 was detected in 2 of 80 samples (2.5%), and in these 2 cases, high-risk HPV was not detected in the uterine cervix or oral cavity of the child.
Conclusion: The infection of HPV in maternal milk is rare (2/80), vertical transmission through maternal milk was not detected in this study (0/80). HPV infection through maternal milk may occur, but its likelihood is low.
Journal Title
Journal of Obstetrics and Gynaecology
ISSN
01443615
13646893
NCID
AA0025872X
Publisher
Taylor & Francis
Volume
31
Issue
6
Start Page
503
End Page
506
Published Date
2011-08-08
Remark
Figure なし
Rights
This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Obstetrics and Gynaecology on 08/08/2011, available online: http://www.tandfonline.com/10.3109/01443615.2011.570814.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
University Hospital
Medical Sciences