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ID 114702
Author
Iwasa, Masami Tokushima University
Ikegame, Akishige Tokushima University
Maruhashi, Tomoko Tokushima prefecture Naruto hospital
Sumitani, Ryohei Tokushima University
Uemura, Munenori Tokushima University
Takahashi, Mamiko Tokushima University
Oda, Asuka Tokushima University
Keywords
adenosine deaminase
multiple myeloma
pleural effusion
Content Type
Journal Article
Description
A 50-year-old man with immunoglobulin A type multiple myeloma (MM) was referred to our hospital after bortezomib therapy. He had high alkaline phosphatase and lactate dehydrogenase levels. Computed tomography showed osteolytic and osteoblastic bone lesions. Response to salvage chemotherapy was temporary, and he developed a right pleural effusion with high adenosine deaminase (ADA) levels. He died from bleeding associated with a pelvic bone fracture 9 months later. ADA mRNA expression and ADA secretion of the MM cells from the patient were higher than those from myeloma cell lines tested. Clinical relevance of high ADA expression in MM cells is warranted.
Journal Title
International Journal of Myeloma
ISSN
21873143
NCID
AA12766965
Publisher
Japanese Society of Myeloma
Volume
7
Issue
1
Start Page
1
End Page
5
Published Date
2017
EDB ID
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital