Oyama, Takuro Tokushima University Tokushima University Educator and Researcher Directory
Kakuta, Nami Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Mita, Naoji Tokushima University KAKEN Search Researchers
Kawahito, Shinji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tanaka, Katsuya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tsutsumi, Yasuo M. Tokushima University KAKEN Search Researchers
Jelly-type oral nutritional supplement
Thesis or Dissertation
Background & aims: Many studies have reported the effects of preoperative clear fluid carbohydrate supplements; however, few studies have reported the effects of preoperative jelly-type carbohydrate supplements. This study aimed to assess the effect of a jelly-type oral nutritional supplement (ONS) on metabolism, redox balance by using various surrogate markers and to evaluate its excretion from the stomach.
Methods: This study was conducted according to a crossover design. Participants underwent a control experiment whereby they fasted after dinner and only ingested water until the experiment. The remaining participants underwent an ONS experiment whereby they ingested 400 g of ONS before bed and another 400 g at 7:00 am. Blood samples were collected at 9:00 am. After a break of at least 24 h, participants underwent the alternate experiment.
Results: Thirty minutes after intake of jelly, the gastric antrum appeared flat (the same result as that at baseline) on ultrasonography. The ONS group showed significantly lower serum free fatty acid levels (100 μEq/L, p = 0.027, vs. 327 μEq/L, n = 6), total ketone bodies levels, 3-MH/creatinine levels, and oxidative stress surrogate markers. Serum insulin levels were significantly higher and participant's satisfaction was improved in the ONS group.
Conclusions: We have the limitations of our methodologies as surrogate markers, compared with direct measurement of lipolysis, proteolysis and redox balance regulation. But Jelly-type ONS suppresses the catabolism of adipose tissue and muscle protein, decreases oxidative stress and improves patient satisfaction in healthy participants, without any increased risk of aspiration.
Clinical Nutrition Experimental
Elsevier|European Society for Clinical Nutrition and Metabolism
© 2018 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
|DOI (Published Version)|
|URL ( Publisher's Version )|
k3357_abstract_review.pdf 187 KB
k3357_fulltext.pdf 657 KB
|MEXT report number||
Doctor of Medical Science