| ID | 111528 |
| Title Alternative | The molecular genetics of multiple endocrine neoplasia type 2A and 2B
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| Author |
Yoshimoto, Katsuhiko
The University of Tokushima
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| Keywords | 10q 11.2
Loss of heterozygosity
Ret proto-oncogene
Mutation
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| Content Type |
Journal Article
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| Description | Multiple endocrine neoplasia (MEN) type 2A (MEN 2A) and type 2B (MEN 2B) are dominantly inherited with a predisposition to endocrine tumors. The responsible genes for MEN 2A and 2B have recently been localized to chromosome 10q 11.2 by genetic and physical mapping. The DNA segment encompasses the RET proto-oncogene. This is a receptor tyrosine kinase gene, which is expressed in medullary thyroid carcinoma and pheochromocytoma. Point mutations in the cysteine-rich domain of the RET were demonstrated in patients with MEN 2A. The cosegregation of these mutations and disease in MEN 2A families indicates that they possess a predisposition endocrine organs to develop into tumors. Biological assesment of the mutant forms in cell culture and transgenic mouse lines should provide further insight as to the role of the RET in the tumor development.
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| Journal Title |
Japanese journal of clinical medicine
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| ISSN | 00471852
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| NCID | AN00198641
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| Publisher | 日本臨牀社
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| Volume | 52
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| Issue | 4
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| Start Page | 1081
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| End Page | 1086
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| Published Date | 1994-04
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| EDB ID | |
| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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| departments |
Oral Sciences
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