ID | 111467 |
Author |
Wang, Di
The University of Tokushima
Iwata, Fusako
Otsuka Pharmaceutical Co.
Muraguchi, Masahiro
Otsuka Pharmaceutical Co.
Ooga, Keiko
Otsuka Pharmaceutical Co.
Ohmoto, Yasukazu
Otsuka Pharmaceutical Co.
Takai, Masaaki
Otsuka Pharmaceutical Co.
Mori, Toyoki
Otsuka Pharmaceutical Co.
|
Keywords | salivary composition
water channel
aquaporin-5
lipid raft
salivary flow rate
|
Content Type |
Journal Article
|
Description | Saliva samples are useful for noninvasive diagnosis of oral and systemic diseases. The water channel protein aquaporin-5 (AQP5) is released into human saliva. Salivary AQP5 levels show a diurnal variation with the secretion of high levels during the waking hours. An age-related decrease in salivary AQP5 levels parallels a decrease in the volume of saliva. Cevimeline, a muscarinic acetylcholine receptor (mAChR) agonist, induces the release of AQP5. Changes in salivary AQP5 levels after cevimeline administration occur simultaneously with changes in saliva flow rate. AQP5 and lipid rafts are released separately from human salivary glands upon M3 mAChR stimulation. In patients with diabetes mellitus or Sjögren’s syndrome, a decrease in salivary secretion occurs concomitantly with low salivary AQP5 levels. Salivary AQP5 levels correlate with salivary secretion in both healthy and disease states, suggesting that changes in salivary AQP5 levels can be used as an indicator of salivary flow rate and the effect of M3 mAChR agonists on human salivary glands.
|
Journal Title |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
|
NCID | AA11166929
AA12022913
|
Publisher | Faculty of Medicine Tokushima University
|
Volume | 56
|
Issue | Supplement
|
Start Page | 350
|
End Page | 353
|
Sort Key | 350
|
Published Date | 2009-12
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Oral Sciences
|